Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Vitamin C (as ascorbic acid)
40 mg
44%
Thiamin (as thiamin HCl)
60 mg
5000%
Riboflavin (as riboflavin and riboflavin-5-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
50 mg
313%
Vitamin B6 (from pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2941%
Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt) (Quatrefolic®)
400 mcg DFE
100%
Vitamin B12 (as methylcobalamin)
1000 mcg
41677%
Biotin
600 mcg
2000%
Pantothenic Acid (as d-calcium pantothenate)
100 mg
2000%
Top Medical Research Studies
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
Read More
8
We explored how N(1)-methylnicotinamide (MNA+) can improve blood vessel relaxation, particularly in those with high cholesterol. The study involved both healthy and hypercholesterolemic participants taking MNA+ and demonstrated significant improvements in flow-mediated dilation, which is linked to enhanced nitric oxide (NO) production.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
This increase in NO bioavailability indicates that MNA+ could play a helpful role in managing conditions like hypercholesterolemia. Overall, our findings suggest MNA+ may be a promising avenue for addressing endothelial issues related to high cholesterol.
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9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
Read More
Most Useful Reviews
9
Lowered blood sugar
5 people found this helpful
The product is excellent for my diabetes. I noticed that after consuming it, my sugar levels decreased significantly, from around 13 or 12 to 9 or even 8. I initially purchased it to boost immunity, but its effects on my blood sugar were a pleasant surprise. The quality of the product is high, with great ingredients, and the quantity is sufficient for a month.
Read More
7.5
Improved energy levels
3 people found this helpful
This complex is recommended for lowering homocysteine levels while planning for pregnancy, being rich in vitamin B. I take one capsule with my morning meal. I’ve noticed an increase in my energy, and my hair and nails appear healthier. I would highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.5
- All Researches
9
We explored the effectiveness of a dietary supplement combining red yeast rice and other natural compounds for lowering cholesterol in children with high cholesterol.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
In a study involving 84 children and adolescents, the supplement significantly decreased total cholesterol and harmful LDL cholesterol after 6 and 16 months. However, there were no notable changes in HDL cholesterol or triglycerides.
Interestingly, those who had been taking phytosterols saw even better results after starting the supplement. Overall, this treatment appears safe and effective, but more research is needed to confirm these findings in larger groups.
Read More
9
We aimed to understand how plasma niacin, an important B vitamin, relates to high cholesterol levels, particularly in individuals with diabetes. In our study involving 2,647 participants, we found that higher levels of plasma niacin were linked to a significantly lower risk of hyperlipidemia in those with diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
This connection didn’t hold true for nondiabetic participants. Interestingly, our results showed consistent benefits across various subgroups, indicating that niacin might play a promising role in cholesterol management for diabetic patients, though more research is necessary for those without diabetes.
Read More
9
We aimed to explore whether a low daily dose of monacolin K from red yeast rice (RYR) could help lower cholesterol levels. In a well-designed, randomized, double-blind, placebo-controlled study, 142 participants with high cholesterol took either RYR or a placebo for 12 weeks.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Participants taking RYR saw a significant drop in low-density lipoprotein cholesterol (LDL-C) by 14.8% and total cholesterol by 11.2%. Impressively, over half reached the recommended LDL-C levels. However, those who received the placebo showed no notable changes.
This study suggests that a small daily dose of monacolin K can be effective in helping manage cholesterol levels.
Read More
9
We examined the effectiveness of nutraceuticals in lowering cholesterol levels and blood pressure for patients with high cholesterol and hypertension. Over six months, 66 participants took a daily tablet containing red yeast rice, policosanol, berberine, folic acid, and coenzyme Q10 alongside usual diet management.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
The results showed significant reductions in total cholesterol and LDL cholesterol, while HDL levels remained unchanged. Importantly, no improvements were observed in the control group. Overall, these nutraceuticals appear safe and effective for enhancing lipid profiles in this specific patient group.
Read More
9
Niacin reduces cholesterol and oxidative stress
We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Lowered blood sugar
5 people found this helpful
The product is excellent for my diabetes. I noticed that after consuming it, my sugar levels decreased significantly, from around 13 or 12 to 9 or even 8. I initially purchased it to boost immunity, but its effects on my blood sugar were a pleasant surprise. The quality of the product is high, with great ingredients, and the quantity is sufficient for a month.
Read More
7.5
Improved energy levels
3 people found this helpful
This complex is recommended for lowering homocysteine levels while planning for pregnancy, being rich in vitamin B. I take one capsule with my morning meal. I’ve noticed an increase in my energy, and my hair and nails appear healthier. I would highly recommend it.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. doi:10.3390/biom14121608
- Geng X, Lin Z, Zheng Z, Lin Q, Sun T, et al. Plasma niacin is inversely associated with hyperlipidemia in participants with diabetes among Chinese adults. Nutr Res. 2024;131:54. doi:10.1016/j.nutres.2024.09.006
- Shoman ME, Aboelez MO, Shaykhon MSA, Ahmed SA, Abuo-Rahma GEA, et al. New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity. Mol Divers. 2021;25:673. doi:10.1007/s11030-020-10039-9
- Heinz T, Schuchardt JP, Möller K, Hadji P, Hahn A. Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention. Nutr Res. 2016;36:1162. doi:10.1016/j.nutres.2016.07.005
- Qin X, Li J, Spence JD, Zhang Y, Li Y, et al. Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients. Stroke. 2016;47:2805.
- Mazza A, Lenti S, Schiavon L, Zuin M, D'Avino M, et al. Nutraceuticals for Serum Lipid and Blood Pressure Control in Hypertensive and Hypercholesterolemic Subjects at Low Cardiovascular Risk. Adv Ther. 2015;32:680. doi:10.1007/s12325-015-0229-x
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. doi:10.1186/1475-2891-12-7
- Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28
- Domagala TB, Szeffler A, Dobrucki LW, Dropinski J, Polanski S, et al. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels. Hypertension. 2012;59:825. doi:10.1161/HYPERTENSIONAHA.111.183210
- Marazzi G, Cacciotti L, Pelliccia F, Iaia L, Volterrani M, et al. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Adv Ther. 2011;28:1105. doi:10.1007/s12325-011-0082-5
